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Article

Myosin-1a is critical for normal brush border structure and composition.

Molecular biology of the cell - 1 May 2005

Tyska Matthew J, Mackey Andrew T, Huang Jian-Dong, Copeland Neil G, Jenkins Nancy A, Mooseker Mark S

Abstract excerpt

To develop our understanding of myosin-1a function in vivo, we have created a mouse line null for the myosin-1a gene. Myosin-1a knockout mice demonstrate no overt phenotypes at the whole animal level but exhibit significant perturbations and signs of stress at the cellular level. Among these are defects in microvillar membrane morphology, distinct changes in brush-border organization, loss of numerous...

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Identifiers

PMID: 15758024
DOI: 10.1091/mbc.e04-12-1116
PMCID: PMC1087248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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