Article

The histone methyltransferase SETD2 regulates HIV expression and latency through a post-transcriptional mechanism

2023-12-15

Abstract excerpt

HIV can enter a state of transcriptional latency in CD4 T cells, allowing the virus to evade the host immune system and persist during antiretroviral therapy. Thus, understanding the mechanisms that drive HIV latency, and developing strategies to reactivate viral expression in latently infected cells, are key goals for achieving a cure for HIV. The full spectrum of mechanisms behind the regulation of HIV expressio...

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Literature Corpus work: 55133dab-9668-569c-a82e-e11a858e819c
DOI: 10.1101/2023.12.15.571871

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