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HSV-2 triggers upregulation of MALAT1 in CD4+ T cells and promotes HIV latency reversal

20 Apr 2023

Abstract excerpt

Herpes simplex virus type 2 (HSV-2) coinfection is associated with increased HIV-1 viral loads and expanded tissue reservoirs, but the mechanisms are not well defined. HSV-2 recurrences result in an influx of activated CD4+ T cells to sites of viral replication and an increase in activated CD4+ T cells in peripheral blood. We hypothesized that HSV-2 induces changes in these cells that facilitate HIV-1...

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PMID: 37079384
DOI: 10.1172/jci164317

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