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Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency

1 Mar 2017

Abstract excerpt

ABSTRACT We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of Polycomb repressive complex 2 (PRC2) and is required for the maintenance of HIV-1 latency in Jurkat T cells. Here we show, by using chromatin immunoprecipitation experiments, that both PRC2 and euchromatic histone-lysine N -methyltransferase 2 (EHMT2), the G9a H3K9me2-3 methyltransferase, are...

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PMID: 28246360
DOI: 10.1128/mbio.00133-17

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