Article
Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics.
Cell reports. Medicine - 21 Apr 2026
Guo Liqiang, Fan Yujia, Sun Huixian, Du Haoran, Xiong Hui, Li Yilin, Zhang Xinyan, Guan Yong, Ren Lingtong, Wang Xuan, Chen Kai, An Yachun, Zhang Xiaohui, Mao Yunuo, Gong Yongfeng, Kong Feng, Qiu Jichuan, Chen Rui, Shi Benkang, Yi Fan, Hu Huili, Zhao Shengtian
Abstract excerpt
Autosomal-dominant polycystic kidney disease (ADPKD) remains refractory to curative therapy partly due to the lack of human models that recapitulate its adult-onset nature, genetic context, and multi-segment origin. Here, we established expandable, multi-lineage adult renal organoids (MAROs) directly from surgical specimens of ADPKD patients and healthy donors, creating a three-dimensional (3D) high-content...
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