Article
Investigational agents for autosomal dominant polycystic kidney disease: preclinical and early phase study insights.
Expert opinion on investigational drugs - 1 May 2024
Capelli Irene, Lerario Sarah, Ciurli Francesca, Berti Gian Marco, Aiello Valeria, Provenzano Michele, La Manna Gaetano
Abstract excerpt
INTRODUCTION: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is the most common inherited kidney condition caused by a single-gene mutation. It leads patients to kidney failure in more than 50% of cases by the age of 60, and, given the dominant inheritance, this disease is present in the family history in more than 90% of cases. AREAS COVERED: This review aims to analyze the set of preclinical and...
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