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Article

Kidney organoid models of polycystic kidney disease: challenges and future directions.

American journal of physiology. Renal physiology - 1 Jul 2025

Afrin Humayra, Qamar Usama, Robichaud Jielu Hao, Ellabbad Mohammad, Harris Peter C, Gupta Navin

Abstract excerpt

Kidney organoids are an increasingly established model of polycystic kidney disease (PKD). Derived from human pluripotent stem cells (hPSCs), organoids may be generated from induced pluripotent stem cells (iPSCs) of patients that bear naturally occurring mutations or from CRISPR mutant hPSCs by virtue of their genetic tractability. PKD is the leading inheritable cause of kidney failure (KF), accounting for...

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Organoids
Phenotype
Induced Pluripotent Stem Cells
Kidney
Polycystic Kidney, Autosomal Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polycystic Kidney Diseases

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Identifiers

PMID: 40499561
DOI: 10.1152/ajprenal.00116.2025
PMCID: PMC12794858

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