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HLA-A*26:01 is associated with vertebral endplate bone marrow lesions (Modic changes) in chronic low back pain: a novel immune-genetic link

2025-09-30

Abstract excerpt

<h4>Objectives</h4> Modic changes (MC) are vertebral endplate bone marrow lesions frequently observed in patients with chronic low back pain (CLBP), but their immunogenetic underpinnings remain unknown. We investigated HLA allele associations to uncover immune-mediated mechanisms and potential biomarkers for patient stratification. <h4>Methods</h4> We analysed the blood transcriptome from 257 patients with CLBP...

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Literature Corpus work
5506a178-76d5-562e-b804-5ff99d5e8183
DOI
10.1101/2025.09.29.25336889
Open publication

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