The dichotomy between disease phenotype databases and the implications for understanding complex diseases involving the major histocompatibility complex.

Abstract excerpt

Many genes related to innate and adaptive immunity reside within the major histocompatibility complex (MHC) and have been associated with a multitude of complex, immune-related disorders. Despite years of genetic study, this region has seen few causative determinants discovered for immune-mediated diseases. Reported associations have been curated in various databases including the Genetic Association Database,...

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