Characteristics of immune cells and causal relationship with chondromalacia: A two-sample, bidirectional mendelian randomization study.

Abstract excerpt

Chondromalacia, characterized by the softening of cartilage, is a prevalent condition affecting joint health with complex etiology. The immune system's role in its pathogenesis has been implicated but remains to be fully elucidated. To address a critical knowledge gap, we conducted a two-sample Mendelian randomization analysis of 731 immune cell phenotypes, assessing parameters like fluorescence, cell count, and...

Topics

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• Genetic Predisposition to Disease
• Mendelian Randomization Analysis
• Phenotype
• Polymorphism, Single Nucleotide
• Risk Factors