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Genome-wide Association Analysis Across 16,956 Patients Identifies a Novel Genetic Association Between BMP6, NIPAL1, CNGA1 and Spondylosis.

Spine - 1 Jun 2021

Zhang Yanfei, Grant Ryan A, Shivakumar Manu K, Zaleski Michael, Sofoluke Nelson, Slotkin Jonathan R, Williams Marc S, Lee Ming Ta Michael

Abstract excerpt

STUDY DESIGN: A case-control genome-wide association study (GWAS) on spondylosis. OBJECTIVE: Leveraging Geisinger's MyCode initiative's multimodal dataset, we aimed to identify genetic associations with degenerative spine disease. SUMMARY OF BACKGROUND DATA: Degenerative spine conditions are a leading cause of global disability; however, the genetic underpinnings of these conditions remain under-investigated....

Topics

Bone Morphogenetic Protein 6
Case-Control Studies
Cation Transport Proteins
Cyclic Nucleotide-Gated Cation Channels
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spondylosis

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PMID: 33332786
DOI: 10.1097/BRS.0000000000003880

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