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Mitophagy in maintaining skeletal muscle mitochondrial proteostasis and metabolic health with ageing

10 Aug 2017

Abstract excerpt

Skeletal muscle is important for overall functionality and health. Ageing is associated with an accumulation of damage to mitochondrial DNA and proteins. In particular, damage to mitochondrial proteins in skeletal muscle, which is a loss of mitochondrial proteostasis, contributes to tissue dysfunction and negatively impacts systemic health. Therefore, understanding the mechanisms underlying the regulation of...

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PMID: 28795394
DOI: 10.1113/jp274337

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