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Mitophagy: An Emerging Role in Aging and Age-Associated Diseases

26 Mar 2020

Abstract excerpt

Mitochondrial dysfunction constitutes one of the hallmarks of aging and is characterized by irregular mitochondrial morphology, insufficient ATP production, accumulation of mitochondrial DNA (mtDNA) mutations, increased production of mitochondrial reactive oxygen species (ROS) and the consequent oxidative damage to nucleic acids, proteins and lipids. Mitophagy, a mitochondrial quality control mechanism enabling...

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PMID: 32274386
DOI: 10.3389/fcell.2020.00200

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