Harnessing Mitophagy for Therapeutic Advances in Aging and Chronic Neurodegenerative Diseases

Abstract excerpt

Introduction: Mitophagy, the selective degradation of damaged mitochondria, is essential for maintaining cellular health and function, particularly in high-energy demanding post-mitotic cells like neurons and in microglial cells. Aging results in impaired mitophagy, leading to mitochondrial dysfunction, oxidative stress, the release of damage-associated proteins (DAMPs), and neuroinflammation, which contribute to...

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• Autophagy in Disease and Therapy
• Calcium signaling and nucleotide metabolism
• Sleep and Wakefulness Research

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Literature Corpus work

56b0893d-5093-5d18-894e-ccff241df669

DOI

10.3390/neuroglia5040026