Article

PEX1 is essential for the glycosome biogenesis and trypanosomatid parasite survival

2023-08-06

Abstract excerpt

Trypanosomatid parasites are kinetoplastid protists that compartmentalize glycolytic enzymes in unique peroxisome-related organelles called glycosomes. The heterohexameric AAA-ATPase complex of PEX1-PEX6 is anchored to the peroxisomal membrane and functions in the export of matrix protein import receptor PEX5 from the peroxisomal membrane. Defects in PEX1, PEX6 or their membrane anchor causes dysfunction of peroxi...

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Literature Corpus work: 54ed97af-5a1e-583b-89f0-1260f94495c4
DOI: 10.1101/2023.08.05.550684

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