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Article

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii.

PLoS pathogens - 1 Feb 2018

Biddau Marco, Bouchut Anne, Major Jack, Saveria Tracy, Tottey Julie, Oka Ojore, van-Lith Marcel, Jennings Katherine Elizabeth, Ovciarikova Jana, DeRocher Amy, Striepen Boris, Waller Ross Frederick, Parsons Marilyn, Sheiner Lilach

Abstract excerpt

Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These parasites are known to be hypersensitive to redox imbalance, yet little is understood about the cellular roles of their various redox regulators. The apicoplast, an essential plastid organelle, is a verified apicomplexan drug target. Nuclear-encoded apicoplast proteins traffic through the ER and...

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Identifiers

PMID: 29470517
DOI: 10.1371/journal.ppat.1006836
PMCID: PMC5823475

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