Article
Compartmentation of enzymes in a microbody, the glycosome, is essential in Trypanosoma brucei.
Journal of cell science - 1 Jul 2002
Guerra-Giraldez Cristina, Quijada Luis, Clayton Christine E
Abstract excerpt
All kinetoplastids contain membrane-bound microbodies known as glycosomes, in which several metabolic pathways including part of glycolysis are compartmentalized. Peroxin 2 is essential for the import of many proteins into the microbodies of yeasts and mammals. The PEX2 gene of Trypanosoma brucei was identified and its expression was silenced by means of tetracycline-inducible RNA interference. Bloodstream-form...
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