Article

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

2024-09-24

Abstract excerpt

Aging can be understood as a consequence of the declining force of natural selection with age. Consistent with this, the antagonistic pleiotropy theory of aging proposes that aging arises from trade-offs that favor early growth and reproduction. However, evidence supporting antagonistic pleiotropy in humans remains limited. Using Mendelian Randomization (MR), we demonstrated that later ages of menarche or first ch...

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Literature Corpus work: f0e465ac-f21a-5222-88e4-8906e917c8a8
DOI: 10.1101/2024.09.23.24314197

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