Article

APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cells

2026-08-06

Abstract excerpt

<h4>ABSTRACT</h4> The amyloid precursor protein (APP) is heavily studied as the source of amyloid beta in Alzheimer’s disease (AD), however, the complex functions of APP remain poorly understood, as does the impact of APP dosage on neurodevelopment. Here we study APP specifically in the context of Trisomy 21. In an effort to reduce APP dosage in trisomy 21 iPSCs, we generated trisomic isogenic lines which vary in...

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Literature Corpus work: 54d21b29-db75-5aa8-9d8d-9dad2cb25e65
DOI: 10.64898/2026.08.05.742240

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