Article

The contribution of APP gene dosage to the molecular phenotypes of Alzheimer's disease in human trisomy 21 neurons

2019-01-01

Abstract excerpt

Down syndrome is a condition caused by trisomy 21 and occurs in 1 out of 700 births. People with trisomy 21 are high risk for developing Alzheimer's disease, a neurodegenerative disease that causes approximately 65% of dementia. People with trisomy 21 develop Alzheimer's disease pathologies by age 30, and about 80% have dementia by the age of 65. Having three copies of the APP gene, which resides on Chr 21 is attr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 11953f1d-2ae6-5611-a2f2-6ca8232d0b5b
DOI: 10.17863/cam.41532

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The contribution of APP gene dosage to the molecular phenotypes of Alzheimer's disease in human trisomy 21 neuronsDOI 10.17863/cam.41532Read

The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived NeuronsSemantic proximity Read

Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer’s Disease phenotypes associated with Down SyndromeSemantic proximity Read

APP Dosage and Extracellular Domain Variants Drive Distinct Defects in Neurogenesis modeled in Down Syndrome iPS cellsSemantic proximity Read

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21Semantic proximity Read

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APPSemantic proximity Read

“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”Semantic proximity Read

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brainSemantic proximity Read

Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo ApproachesSemantic proximity Read

Alzheimer‐like pathology in trisomy 21 cerebral organoids amenable to pharmacological inhibition reveals BACE2 as a gene‐dose‐sensitive AD‐suppressor in human brainSemantic proximity Read

Cell models for Down syndrome-Alzheimer’s disease researchSemantic proximity Read

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoidsSemantic proximity Read

A human embryonic stem cell model of Aβ-dependent chronic progressive neurodegenerationSemantic proximity Read