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Article

App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 30 Jul 2003

Cataldo Anne M, Petanceska Suzana, Peterhoff Corrinne M, Terio Nicole B, Epstein Charles J, Villar Angela, Carlson Elaine J, Staufenbiel Matthias, Nixon Ralph A

Abstract excerpt

Altered neuronal endocytosis is the earliest known pathology in sporadic Alzheimer's disease (AD) and Down syndrome (DS) brain and has been linked to increased Abeta production. Here, we show that a genetic model of DS (trisomy 21), the segmental trisomy 16 mouse Ts65Dn, develops enlarged neurona...

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Identifiers

PMID: 12890772
PMCID: PMC6740714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12890772-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome.PMID 12890772Read ↗

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