Article

Inhibition of Bruton’s tyrosine kinase activity attenuates trauma-induced multiple organ dysfunction in rats

2021-09-24

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> The aim of this study was to investigate (a) the potential of the Bruton’s tyrosine kinase (BTK) inhibitors (BTKi) acalabrutinib and fenebrutinib to reduce multiple organ dysfunction syndrome (MODS) in acute and chronic hemorrhagic shock (HS) rat models and (b) whether treatment with either acalabrutinib or fenebrutinib attenuates BTK, NF-κB and NLRP3 activation in HS. <h4>Ba...

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Literature Corpus work: 54cf0791-d812-5906-a903-61946fb53245
DOI: 10.1101/2021.09.23.460775

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