Article

Immunopathology of Terminal Complement Activation and Complement C5 Blockade Creating a Prosurvival and Organ-protective Phenotype in Trauma

2022-02-07

Abstract excerpt

<h4>Background: </h4> and Purpose: Traumatic hemorrhage (TH) is the leading cause of potentially preventable deaths that occur during the prehospital phase of care. No effective pharmacological therapeutics are available for critical TH patients yet. Here, we identify terminal complement activation (TCA) as a therapeutic target in combat casualties and evaluate the efficacy of TCA inhibitor (nomacopan) on organ da...

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Literature Corpus work: dae666fb-6872-5d9c-ac30-20a5cdc55fb8
DOI: 10.22541/au.164423459.98723938/v1

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