Article
Immunopathology of terminal complement activation and complement C5 blockade creating a pro-survival and organ-protective phenotype in trauma.
British journal of pharmacology - 1 Feb 2023
Yang Zhangsheng, Nunn Miles A, Le Tuan D, Simovic Milomir O, Edsall Peter R, Liu Bin, Barr Johnny L, Lund Brian J, Hill-Pryor Crystal D, Pusateri Anthony E, Cancio Leopoldo C, Li Yansong
Abstract excerpt
BACKGROUND AND PURPOSE: Traumatic haemorrhage (TH) is the leading cause of potentially preventable deaths that occur during the prehospital phase of care. No effective pharmacological therapeutics are available for critical TH patients yet. Here, we identify terminal complement activation (TCA) as a therapeutic target in combat casualties and evaluate the efficacy of a TCA inhibitor (nomacopan) on organ damage...
Topics
- Rats
- Animals
- Complement C5
- Shock, Hemorrhagic
- Complement Activation
- Immunologic Factors
- Phenotype