Article

BTK Mediates Inflammation, Mast Cell Activation, and Urothelial Barrier Disruption in IC/BPS model

2025-08-21

Abstract excerpt

<title>Abstract</title> <p>Background Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urinary disorder with unclear pathogenesis. Previous studies identified BTK as a hub gene potentially involved in IC/BPS. This study investigates BTK’s role in mast cell (MC) activation and bladder inflammation. Methods An LL-37-induced IC/BPS rat model and an in vitro MC model were established. BTK expression...

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Literature Corpus work: c5106642-1718-5bbb-ac07-171b7e418064
DOI: 10.21203/rs.3.rs-7182790/v1

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