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Article

Gene-variant specific effects of plasma amyloid-β levels in Swedish autosomal dominant Alzheimer disease.

Alzheimer's research & therapy - 25 Sept 2024

Johansson Charlotte, Thordardottir Steinunn, Laffita-Mesa José, Pannee Josef, Rodriguez-Vieitez Elena, Zetterberg Henrik, Blennow Kaj, Graff Caroline

Abstract excerpt

BACKGROUND: Several blood-based biomarkers offer the opportunity of in vivo detection of brain pathology and neurodegeneration in Alzheimer disease with high specificity and sensitivity, but the performance of amyloid-β (Aβ) measurements remains under evaluation. Autosomal dominant Alzheimer disease (ADAD) with mutations in PSEN1, PSEN2 and APP can be studied as a model for sporadic Alzheimer disease. However,...

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Source

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Identifiers

PMID: 39322953
DOI: 10.1186/s13195-024-01574-w
PMCID: PMC11423518

Genes

PSEN1
APP
PSEN2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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