Article

Quantification of allosteric communications in matrix metalloprotease-1 on alpha-synuclein aggregates and substrate-dependent virtual screening

2021-01-13

Abstract excerpt

Alpha-synuclein (aSyn) has implications in pathological protein aggregations observed in neurodegenerative disorders, including Parkinson’s and Alzheimer’s diseases. There are currently no approved prevention and cure for these diseases. In this context, matrix metalloproteases (MMPs) provide an opportunity because MMPs are broad-spectrum proteases and cleave aSyn. Previously, we showed that allosteric communicati...

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Literature Corpus work: 54add1a6-3639-539b-9696-8d96ae6e580c
DOI: 10.1101/2021.01.11.426304

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