Article

Structural Dynamics and Catalytic Mechanism of ATP13A2 (PARK9) from Simulations

2021-06-01

Abstract excerpt

ATP13A2 is a gene encoding a protein of the P5B subfamily of ATPases and is a PARK gene. Molecular defects of the gene are mainly associated with variations of Parkinson’s Disease (PD). Despite the established importance of the protein in regulating neuronal integrity, the three-dimensional structure of the protein currently remains unresolved crystallographically. We have modelled the structure and reactivity of...

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Literature Corpus work: 54abc517-3ad3-5999-8eef-876d3ae7aa81
DOI: 10.1101/2021.06.01.446648

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