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Computational studies on the functional and structural impact of pathogenic mutations in enzymes.

Protein science : a publication of the Protein Society - 1 Apr 2025

Dissanayake Upeksha C, Roy Arkanil, Maghsoud Yazdan, Polara Sarthi, Debnath Tanay, Cisneros G Andrés

Abstract excerpt

Enzymes are critical biological catalysts involved in maintaining the intricate balance of metabolic processes within living organisms. Mutations in enzymes can result in disruptions to their functionality that may lead to a range of diseases. This review focuses on computational studies that investigate the effects of disease-associated mutations in various enzymes. Through molecular dynamics simulations,...

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Identifiers

PMID: 40116283
DOI: 10.1002/pro.70081
PMCID: PMC11926659

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