Article

Mechanistic Insights into the Wilson Disease Protein MBD6 and Its Interaction with the Chaperone Atox1 underlying the G626A Mutation

2026-02-09

Abstract excerpt

<title>Abstract</title> <p>The human transporter ATP7B plays a critical role in maintaining hepatic copper homeostasis, a process mediated by the specific interaction between its metal binding domain (MBD) and copper chaperone Atox1. The G626A mutation in MBD are known to cause the fatal hepatoneurological disorder Wilson disease (WD). However, the interaction mode between MBD and Atox1, as well as the molecular...

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Literature Corpus work: 674d451f-4f56-5ee0-a80d-073c6684524f
DOI: 10.21203/rs.3.rs-8691483/v1

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