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Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations

2024-12-05

Abstract excerpt

Inorganic pyrophosphatases, or PPases, are ubiquitous enzymes whose activity is necessary for a large number of biosynthetic reactions. Catalytic function of PPases is dependent on certain conformational changes that have been previously characterized based on the comparison of the crystal structures of various complexes. The current work describes the conformational dynamics of a structural model of human mitocho...

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Literature Corpus work
9a1a0c95-aaff-51e1-b2d2-ce974937f1b9
DOI
10.20944/preprints202412.0441.v1
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Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic MutationsDOI 10.20944/preprints202412.0441.v1
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