Article

Simulations of Pathogenic E1α Variants: Allostery and Impact on Pyruvate Dehydrogenase Complex-E1 Structure and Function

2022-05-17

Abstract excerpt

<h4>ABSTRACT</h4> Pyruvate dehydrogenase complex (PDC) deficiency is a major cause of primary lactic acidemia resulting in high morbidity and mortality, with limited therapeutic options. The E1 component of the mitochondrial multienzyme PDC (PDC-E1) is a symmetric dimer of heterodimers (αβ/α’β’) encoded by the PDHA1 and PDHB genes, with two symmetric active sites each consisting of highly conserved phosphorylat...

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Literature Corpus work: 1bb2092a-30ac-548c-9d9d-5c51c4202f3b
DOI: 10.1101/2022.05.17.492373

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