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Article

A role for actin flexibility in thin filament-mediated contractile regulation and myopathy.

Nature communications - 15 May 2020

Viswanathan Meera C, Schmidt William, Franz Peter, Rynkiewicz Michael J, Newhard Christopher S, Madan Aditi, Lehman William, Swank Douglas M, Preller Matthias, Cammarato Anthony

Abstract excerpt

Striated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position tropomyosin such that it impedes actomyosin associations. Impaired relaxation and hypercontractile properties are hallmarks of various muscle disorders....

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Identifiers

PMID: 32415060
DOI: 10.1038/s41467-020-15922-5
PMCID: PMC7229152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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