Article

Alternative splice variants of the mitochondrial fission protein <i>DNM1L</i> /Drp1 regulate mitochondrial dynamics and tumor progression in ovarian cancer

2023-09-20

Abstract excerpt

Aberrant mitochondrial fission/fusion dynamics have been reported in cancer cells. While post translational modifications are known regulators of the mitochondrial fission/fusion machinery, we show that alternative splice variants of the fission protein Drp1 ( DNM1L ) have specific and unique roles in cancer, adding to the complexity of mitochondrial fission/fusion regulation in tumor cells. Ovarian cancer specim...

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Literature Corpus work: 54983454-8d99-56d3-be9c-ee050cad6891
DOI: 10.1101/2023.09.20.558501

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