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Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial function

2025-10-30

Abstract excerpt

<title>Abstract</title> <p> Increasing evidences demonstrate that mitochondrial function is essential for cancer cell survival and metastasis. However, the role of mitochondrial metabolic reprogramming in ovarian cancer progression remains largely unknown. Here, we report that mitochondrial chaperone <italic>BCS1L</italic> generates two major alternative spliced isoforms, a full-length isoform ( <italic>BCS1L...

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Literature Corpus work
9e348844-b6d4-5f24-aa9a-2c4595c847d9
DOI
10.21203/rs.3.rs-7616131/v1
Open publication

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Splice-switching of the oncogenic BCS1L isoform suppresses ovarian cancer progression by disrupting mitochondrial functionDOI 10.21203/rs.3.rs-7616131/v1
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