Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology.

Pharmacology & therapeutics - 1 Sept 2020

Rosdah Ayeshah A, Smiles William J, Oakhill Jonathan S, Scott John W, Langendorf Christopher G, Delbridge Lea M D, Holien Jessica K, Lim Shiang Y

Abstract excerpt

Mitochondria are dynamic organelles constantly undergoing fusion and fission. A concerted balance between the process of mitochondrial fusion and fission is required to maintain cellular health under different physiological conditions. Mutation and dysregulation of Drp1, the major driver of mitochondrial fission, has been associated with various neurological, oncological and cardiovascular disorders. Moreover,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dynamins
Share to Mitochondria

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondrial Dynamics

Share to Mitochondrial Proteins

Share to Mutation

Share to Protein Isoforms

Source

Identifiers

PMID: 32473962
DOI: 10.1016/j.pharmthera.2020.107594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology.PMID 32473962Read ↗

Mitochondrial fission and fusion in secondary brain damage after CNS insultsSemantic proximity Read ↗

The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.Semantic proximity Read ↗

DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergeticsSemantic proximity Read ↗

Targeting Drp1 and mitochondrial fission for therapeutic immune modulationSemantic proximity Read ↗

Role of Mitochondrial Dynamics in Heart DiseasesSemantic proximity Read ↗

Inhibitors of Mitochondrial Fission as a Therapeutic Strategy for Diseases with Oxidative Stress and Mitochondrial DysfunctionSemantic proximity Read ↗

Alternative splice variants of the mitochondrial fission protein <i>DNM1L</i> /Drp1 regulate mitochondrial dynamics and tumor progression in ovarian cancerSemantic proximity Read ↗

The role of mitochondrial dynamics in diseaseSemantic proximity Read ↗

Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasisSemantic proximity Read ↗

Mitochondrial Fission Protein 1: Emerging Roles in Organellar Form and Function in Health and DiseaseSemantic proximity Read ↗

[Mitochondrial morphology and dynamics: actors, mechanisms and functions].Semantic proximity Read ↗

Serine 39 in the GTP-binding domain of Drp1 is involved in shaping mitochondrial morphology.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.