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Posttranscriptional regulation of neurofilament proteins and tau in health and disease

29 Oct 2022

Abstract excerpt

Neurofilament and tau proteins are neuron-specific cytoskeletal proteins that are enriched in axons, regulated by many of the same protein kinases, interact physically, and are the principal constituents of neurofibrillary lesions in major adult-onset dementias. Both proteins share functions related to the modulation of stability and functions of the microtubule network in axons, axonal transport and scaffolding...

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PMID: 36441047
DOI: 10.1016/j.brainresbull.2022.10.017

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