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Article

A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer’s disease

2 May 2021

Abstract excerpt

Tauopathies, including Alzheimer's disease (AD) and frontotemporal lobar degeneration with Tau pathology (FTLD-tau), are a group of neurodegenerative disorders characterized by Tau hyperphosphorylation. Post-translational modifications of Tau such as phosphorylation and truncation have been demonstrated to be an essential step in the molecular pathogenesis of these tauopathies. In this work, we demonstrate the...

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PMID: 33934221
DOI: 10.1007/s00401-021-02317-z

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