Article

TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disorders

2024-01-22

Abstract excerpt

Nuclear clearance and cytoplasmic aggregation of the RNA-binding protein TDP-43 are observed in many neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS) and fronto- temporal dementia (FTD). Although TDP-43 dysregulation of splicing has emerged as a key event in these diseases, TDP-43 can also regulate polyadenylation; yet, this has not been adequately studied. Here, we applied the dynamic an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8540a7d0-4ecf-513b-b978-75ac53e564ea
DOI: 10.1101/2024.01.22.576709

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in ALS/FTD and related disordersDOI 10.1101/2024.01.22.576709Read

TDP-43 dysregulation of polyadenylation site selection is a defining feature of RNA misprocessing in amyotrophic lateral sclerosis and frontotemporal dementiaSemantic proximity Read

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes.Semantic proximity Read

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changesSemantic proximity Read

TDP-43 loss induces extensive cryptic polyadenylation in ALS/FTDSemantic proximity Read

Pathogenic Mutation of TDP-43 Impairs RNA Processing in a Cell Type-Specific Manner: Implications for the Pathogenesis of ALS/FTLD.Semantic proximity Read

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathySemantic proximity Read

Integrative multiomic analysis links TDP-43-driven splicing defects to cascading proteomic disruption of ALS/FTD pathwaysSemantic proximity Read

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathySemantic proximity Read

TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegenerationSemantic proximity Read

Familial ALS/FTD-associated RNA-binding deficient TDP-43 mutants cause neuronal and synaptic transcript dysregulation in vitroSemantic proximity Read

Novel and known transcriptional targets of ALS/FTD protein TDP-43: Meta-analysis and interactive graphical databasesSemantic proximity Read