Article
Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.
Cell metabolism - 2 Oct 2018
Lin Guang, Lee Pei-Tseng, Chen Kuchuan, Mao Dongxue, Tan Kai Li, Zuo Zhongyuan, Lin Wen-Wen, Wang Liping, Bellen Hugo J
Abstract excerpt
Mutations in PLA2G6 (PARK14) cause neurodegenerative disorders in humans, including autosomal recessive neuroaxonal dystrophy and early-onset parkinsonism. We show that loss of iPLA2-VIA, the fly homolog of PLA2G6, reduces lifespan, impairs synaptic transmission, and causes neurodegeneration. Phospholipases typically hydrolyze glycerol phospholipids, but loss of iPLA2-VIA does not affect the phospholipid...
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