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Article

Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer.

Nature communications - 19 Mar 2026

Lin Zhi-Hao, Xue Nai-Jia, Liu Yi, Zhang Feng, Si Xiao-Li, Zheng Ran, Gu Lu-Yan, Li Yao-Lin, Fan Yi, Tian Jun, Oertel Wolfgang H, Seo Hyemyung, Pu Jia-Li, Zhang Bao-Rong

Abstract excerpt

Mutations in the phospholipase A2 group VI (PLA2G6) gene have been linked to autosomal recessive Parkinson's disease (PD), yet the molecular mechanisms remain poorly understood. This study provides the in vitro and in vivo evidence, specifically in dopaminergic neurons derived from patients with PD, that PLA2G6 loss-of-function disrupts the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM), a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41857015
DOI: 10.1038/s41467-026-70752-1
PMCID: PMC13272647

Genes

PLA2G6
VDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Parkinson's disease-associated PLA2G6 protects IP3R1 protein to control ER-mitochondria tethering and Ca2+ transfer.PMID 41857015Read ↗

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