Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.

doi:10.1016/j.celrep.2020.02.100

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Article

Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.

Cell reports - 17 Mar 2020

Selyutina Anastasia, Persaud Mirjana, Simons Lacy M, Bulnes-Ramos Angel, Buffone Cindy, Martinez-Lopez Alicia, Scoca Viviana, Di Nunzio Francesca, Hiatt Joseph, Marson Alexander, Krogan Nevan J, Hultquist Judd F, Diaz-Griffero Felipe

Abstract excerpt

Disruption of cyclophilin A (CypA)-capsid interactions affects HIV-1 replication in human lymphocytes. To understand this mechanism, we utilize human Jurkat cells, peripheral blood mononuclear cells (PBMCs), and CD4+ T cells. Our results show that inhibition of HIV-1 infection caused by disrupting CypA-capsid interactions is dependent on human tripartite motif 5α (TRIM5αhu), showing that TRIM5αhu restricts HIV-1...

Topics

Adult
Antiviral Restriction Factors
CD4-Positive T-Lymphocytes
Capsid
Cell Line
Cyclophilin A
Cyclosporine
HIV Infections
HIV-1
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Mutation

Protein Binding

Reverse Transcription

Tripartite Motif Proteins

Ubiquitin-Protein Ligases

Source

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Identifiers

PMID: 32187548
DOI: 10.1016/j.celrep.2020.02.100
PMCID: PMC7363000

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