Article
Cyclophilin A modulates the sensitivity of HIV-1 to host restriction factors.
Nature medicine - 1 Sept 2003
Towers Greg J, Hatziioannou Theodora, Cowan Simone, Goff Stephen P, Luban Jeremy, Bieniasz Paul D
Abstract excerpt
Many mammalian species express restriction factors that confer host resistance to retroviral infection. Here we show that HIV-1 sensitivity to restriction factors is modulated by cyclophilin A (CypA), a host cell protein that binds the HIV-1 capsid protein (CA). In certain nonhuman primate cells, the CA-CypA interaction is essential for restriction: HIV-1 infectivity is increased >100-fold by cyclosporin A (CsA),...
Topics
- Amino Acid Sequence
- Animals
- Aotidae
- Binding Sites
- Capsid
- Carrier Proteins
- Cells, Cultured
- Cyclophilin A
- Cyclosporine
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Gene Products, gag