Article

Aβ-42 sidechain deamidation at Q15 or N27 modulates protein aggregation and alters microglial cytokines and CD68

2025-10-23

Abstract excerpt

The progressive aggregation of amyloid beta (Aβ) monomers into oligomers is a critical factor in Alzheimer’s disease (AD) pathogenesis. Although mutated forms of Aβ have been shown to display altered aggregation dynamics, the specific effects of deamidated Aβ on microglial function remain understudied. Our research group previously found that the deamidated variant Aβ-42-N27D modified Aβ aggregation, reduced neuro...

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Literature Corpus work: 5480fecc-f0e3-54c5-ab6a-8699d127d3db
DOI: 10.1101/2025.10.22.684043

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Aβ-42 sidechain deamidation at Q15 or N27 modulates protein aggregation and alters microglial cytokines and CD68DOI 10.1101/2025.10.22.684043Read

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