Article
Design of non-aggregating variants of Aβ peptide.
Biochemical and biophysical research communications - 24 Oct 2014
Caine Joanne M, Churches Quentin, Waddington Lynne, Nigro Julie, Breheney Kerry, Masters Colin L, Nuttall Stewart D, Streltsov Victor A
Abstract excerpt
Self association of the amyloid-β (Aβ42) peptide into oligomers, high molecular weight forms, fibrils and ultimately neuritic plaques, has been correlated with progressive cognitive decline in Alzheimer's disease. Thus, insights into the drivers of the aggregation pathway have the capacity to significantly contribute to our understanding of disease mechanism. Functional assays and a three-dimensional crystal...
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