Article

Modulating Amyloid-β Toxicity: In Vitro Analysis of Aβ42(G37V) Variant Impact on Aβ42 Aggregation and Cytotoxicity

2024-11-13

Abstract excerpt

Alzheimer's disease (AD) is primarily driven by the formation of toxic amyloid-β (Aβ) aggregates, with Aβ42 being a pivotal contributor to disease pathology. This study investigates a novel approach to mitigating Aβ42-induced toxicity by co-assembling Aβ42 with its G37V variant (Aβ42(G37V)), where Gly at position 37 is substituted with Valine. Using a combination of Thioflavin-T (Th-T) fluorescence assays, We...

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Literature Corpus work: 6b0802d1-7e5b-5184-abc5-45d465f8cafd
DOI: 10.20944/preprints202411.0999.v1

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