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α7-nicotinic acetylcholine receptor and mutated α-synuclein interact in motor behavior and nigrostriatal dopamine - findings with potential relevance for a protective effect of cigarette smoking and Parkinson’s disease

2024-09-20

Abstract excerpt

Parkinson’s disease (PD) occurs less frequently in cigarette smokers than in non-smokers. Assuming that nicotinic acetylcholine receptors are periodically active by activation through endogenous acetylcholine, we tested whether they act against the effect of α-synuclein, a protein relevant in PD. Transgenic mice with a human α-synuclein containing two mutations that cause familial PD were crossed with mice lacking...

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Literature Corpus work
546b36cb-f3c8-5db4-b0e9-79bf7cefd79a
DOI
10.22541/au.172682657.71360317/v1
Open publication

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α7-nicotinic acetylcholine receptor and mutated α-synuclein interact in motor behavior and nigrostriatal dopamine - findings with potential relevance for a protective effect of cigarette smoking and Parkinson’s diseaseDOI 10.22541/au.172682657.71360317/v1
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