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Article

Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.

Journal of the neurological sciences - 15 Nov 2011

Szego Éva M, Gerhardt Ellen, Outeiro Tiago F, Kermer Pawel

Abstract excerpt

Cognitive dysfunction can be common among Parkinson's disease (PD) patients, and multiplication of the gene α-synuclein (αsyn) increases the risk of dementia. Here, we studied the role of dopamine-depletion and increased αsyn load and aggregation on cholinergic structures in vivo. Wild-type (WT) and mice with A30P αsyn overexpression were treated subacutely with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine...

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Source

Identifiers

PMID: 21774947
DOI: 10.1016/j.jns.2011.06.048

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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