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Article

In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration

15 Jun 2010

Abstract excerpt

Two small-interfering RNAs (siRNAs) targeting alpha-synuclein (alpha-syn) and three control siRNAs were cloned in an adeno-associated virus (AAV) vector and unilaterally injected into rat substantia nigra pars compacta (SNc). Reduction of alpha-syn resulted in a rapid (4 week) reduction in the number of tyrosine hydroxylase (TH) positive cells and striatal dopamine (DA) on the injected side. The level of...

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PMID: 20551914
DOI: 10.1038/mt.2010.115

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