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Article

Parkinsonian phenotypes induced by Synphilin-1 expression are differentially contributed by serotonergic and dopaminergic circuits and suppressed by nicotine treatment.

PloS one - 1 Jan 2023

Carvajal-Oliveros Angel, Dominguez-Baleón Carmen, Sánchez-Díaz Iván, Zambrano-Tipan Diego, Hernández-Vargas René, Campusano Jorge M, Narváez-Padilla Verónica, Reynaud Enrique

Abstract excerpt

Synphilin-1 is a protein encoded by the human SNCAIP gene whose function has yet to be fully understood. However, it has been linked to familial Parkinson's disease (PD). Synphilin-1 is a major component of the Lewy bodies found in neurons in the substantia nigra pars compacta of PD patients. Synphilin-1 expression in serotonergic and/or dopaminergic neurons of Drosophila melanogaster induces neurodegeneration,...

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Identifiers

PMID: 36857384
DOI: 10.1371/journal.pone.0282348
PMCID: PMC9977059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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